Los Tajibos, A Tribute Portfolio Hotel
Santa Cruz's classic resort-style hotel in Equipetrol, part of Tribute Portfolio, with tropical gardens, a renovated main pool, an adults-only pool, spa, five restaurants and bars and Bolivia's largest hotel convention centre.
Hotel Camino Real
A five-star hotel in Equipetrol Norte facing Ventura Mall, with suites of up to 94 square metres, an outdoor pool with water slide, a climate-controlled leisure pool, spa and La Tranquera restaurant.
Hotel Cortez
A long-standing Santa Cruz favourite on Avenida Cristóbal de Mendoza, with a climate-controlled pool, a spa with hydromassage and saunas, La Poza del Bato restaurant and executive suites.
Biocentro Güembé Lodge & Resort
A nature resort near Santa Cruz, set in a biopark with one of South America's largest aviaries, a butterfly house, kayaking lagoons and natural pools in three themed areas.
Swissôtel Santa Cruz de la Sierra
A contemporary five-star Swissôtel on Avenida La Salle in Santa Cruz de la Sierra, with city-view rooms, a rooftop pool, a spa with sauna and hot tub, a restaurant and bar.
Senses Hotel Boutique Plaza
A design hotel a few metres from the cathedral on Santa Cruz's main square, with minimalist rooms and balconies, a rooftop pool and hot tub, a sky bar and Ikirau restaurant.